Ago2 Antibody, Brachyury Antibody, Cd45Ro Antibody, Cdk5 Antibody, Erg Antibody, Foxa2 Antibody, Guinea, Hamster, Helicobacter, Horse, Influenza, Insect, Jmjd3 Antibody, Kangaroo, Killifish, Klf2 Antibody, Lkb1 Antibody, Pig, Rabbit, Raccoon, Rat, Reindeer, Reptile, Zeb2 Antibody

Concanavalin A Hepatitis

In addition to, ConA-treated mice contained elevated numbers of activated pure killer (NK) cells, T cells, and NK T cells, which confirmed sturdy cytotoxic train in opposition to murine lymphoma cells in ex vivo assays. That’s moreover translated proper right into a strongly diminished number of liver nodules upon ConA remedy of colon cancer-bearing mice (colon-26), an affect that was abrogated upon NK cell depletion (Fig. 4A). Of observe, NK cells in immunodeficient nude mice (lacking NKT and T cells) weren’t activated upon ConA remedy, suggesting a job of the adaptive immune system in activating NK cells [74].

Concanavalin A (Con A) is a plant lectin that is purified from jack beans. Con A binds to the mannose residues of various glycoproteins and prompts lymphocytes. When Con A is run to mice, liver harm that can rely upon the activation of T lymphocytes by macrophages occurs (Tiegs et al., 1992).

Because of this truth, the model might allow the study of the pathophysiology of immunologically mediated hepatic points, resembling AIH. TNF-α and IFN-γ play important roles in Con A–induced liver harm (Gantner et al., 1995; Kusters et al., 1996) and IL-10 prevents liver harm on this model (Di Marco et al., 1999; Louis et al., 1997). Blood ranges of IL-2, IL-4, and IFN-γ dramatically improve after administration of Con A (Wang et al., 2012). Major drawbacks of this model embrace the dearth of circulating autoantibodies and quick hepatocyte harm following a single-dose Con A injection, which is not a typical attribute of persistent AIH.

 

Lectins as modulators of autophagy in most cancers immunotherapy

Concanavalin A prompts T cells and pure killer cells and triggers anticancer immune responses

Since ConA is a well-known T cell mitogen it’d moreover set off anticancer immune responses by activating tumor explicit CTLs. Actually, remedy of hepatoma-bearing mice (ML-14a cells) with ConA (7.5 mg/kg) strongly diminished liver tumor formation and prolonged survival, whereby 40% of the animals had been tumor free on the end of the experiment [8]. Lymphocytic infiltrates spherical tumor nodules had been observed in ConA-treated animals, suggesting T cell mediated responses. Actually, the depletion of CD8+ T cells totally abrogated the therapeutic outcomes of ConA, whereas the depletion of CD4+ T cells solely partly prevented ConA-mediated inhibition of tumor formation (Fig. 4A). According to this study, ConA triggered CD4+ and CD8+ T cell activation in mice as confirmed by the upregulated expression of CD69 [74].

 

Concavalin A
Concavalin A

Furthermore, all outcomes had been abrogated in IFNγ knock-out mice, displaying the importance of an vigorous immune response. Nonetheless, the remedy with ConA of hepatoma-bearing SCID mice moreover significantly inhibited liver tumor formation, nevertheless solely on the best dose of 20 mg/kg [8]. As SCID mice lack purposeful lymphocytes, these info counsel a direct cytotoxic influence of ConA in direction of the most cancers cells. Actually, ConA induced direct autophagy-dependent cell demise in these mice (see above paragraph about ConA and most cancers cell demise). Thus, ConA prompts CD8+ CTLs and NK cells that in the reduction of in vivo tumor progress and potentiate ex vivo tumor cell lysis (Fig. 4A).

 

Programmed Cell Death Protein 10 (PDCD10) Antibody

abx236237-100ug 100 ug
EUR 577.2

Programmed Cell Death Protein 10 (PDCD10) Antibody

20-abx214660
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Human Programmed cell death protein 10 (PDCD10)

1-CSB-EP861141HU
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Programmed cell death protein 10(PDCD10) expressed in E.coli

Programmed Cell Death Protein 10 (PDCD10) Antibody (HRP)

20-abx310611
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Programmed Cell Death Protein 10 (PDCD10) Antibody (FITC)

20-abx310612
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Programmed Cell Death Protein 10 (PDCD10) Antibody (Biotin)

20-abx310613
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Human Programmed Cell Death Protein 10 (PDCD10) ELISA Kit

abx382112-96tests 96 tests
EUR 1093.2

Chicken Programmed cell death protein 10, PDCD10 ELISA KIT

ELI-35614c 96 Tests
EUR 1113.6

Human Programmed cell death protein 10, PDCD10 ELISA KIT

ELI-20923h 96 Tests
EUR 988.8

Mouse Programmed cell death protein 10, Pdcd10 ELISA KIT

ELI-14591m 96 Tests
EUR 1038

Programmed Cell Death 5 Protein

20-abx262104
  • EUR 5388.00
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Programmed Cell Death 6 Protein

20-abx262735
  • EUR 393.60
  • EUR 7676.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Programmed Cell Death 4 Protein

20-abx262858
  • EUR 393.60
  • EUR 7676.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Recombinant Programmed Cell Death Protein 6 (PDCD6)

4-RPL096Hu01
  • EUR 593.09
  • EUR 282.00
  • EUR 1894.08
  • EUR 711.36
  • EUR 1302.72
  • EUR 472.80
  • EUR 4555.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Programmed Cell Death Protein 6 expressed in: E.coli

Recombinant Programmed Cell Death Protein 5 (PDCD5)

4-RPL105Hu01
  • EUR 580.19
  • EUR 278.40
  • EUR 1845.70
  • EUR 695.23
  • EUR 1270.46
  • EUR 463.20
  • EUR 4434.24
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Programmed Cell Death Protein 5 expressed in: E.coli

Recombinant Programmed Cell Death Protein 1 (PDCD1)

4-RPA751Hu01
  • EUR 612.44
  • EUR 286.80
  • EUR 1966.66
  • EUR 735.55
  • EUR 1351.10
  • EUR 484.80
  • EUR 4736.64
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Programmed Cell Death Protein 1 expressed in: E.coli

Recombinant Programmed Cell Death Protein 1 (PDCD1)

4-RPA751Ra01
  • EUR 603.84
  • EUR 285.60
  • EUR 1934.40
  • EUR 724.80
  • EUR 1329.60
  • EUR 480.00
  • EUR 4656.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Programmed Cell Death Protein 1 expressed in: E.coli

Recombinant Human Programmed Cell Death 5

7-05830 5µg Ask for price

Recombinant Human Programmed Cell Death 5

7-05831 20µg Ask for price

Recombinant Human Programmed Cell Death 5

7-05832 1mg Ask for price

Recombinant Human Programmed Cell Death 6

7-05833 2µg Ask for price

Recombinant Human Programmed Cell Death 6

7-05834 10µg Ask for price

Recombinant Human Programmed Cell Death 6

7-05835 1mg Ask for price

Recombinant Human Programmed cell death protein 10 Protein, His-SUMO, E.coli-100ug

QP8043-ec-100ug 100ug
EUR 489.6

Recombinant Human Programmed cell death protein 10 Protein, His-SUMO, E.coli-10ug

QP8043-ec-10ug 10ug
EUR 240

Recombinant Human Programmed cell death protein 10 Protein, His-SUMO, E.coli-1mg

QP8043-ec-1mg 1mg
EUR 1958.4

Recombinant Human Programmed cell death protein 10 Protein, His-SUMO, E.coli-200ug

QP8043-ec-200ug 200ug
EUR 760.8

Recombinant Human Programmed cell death protein 10 Protein, His-SUMO, E.coli-500ug

QP8043-ec-500ug 500ug
EUR 1272

Recombinant Human Programmed cell death protein 10 Protein, His-SUMO, E.coli-50ug

QP8043-ec-50ug 50ug
EUR 315.6

Programmed Cell Death 6 Interacting Protein

20-abx260576
  • EUR 3433.20
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 25 ug
  • 5 ug

PDCD1/Programmed cell death protein 1

E21-D91 10ug
EUR 411.6

PDCD5 Programmed Cell Death-5 Human Recombinant Protein

PROTO14737 Regular: 20ug
EUR 380.4
Description: PDCD5 Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 125 amino acids and having a molecular mass of 14 kDa.

PDCD6 Programmed Cell Death 6 Human Recombinant Protein

PROTO75340 Regular: 10ug
EUR 380.4
Description: PDCD6 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 211 amino acids (1-191a.a.) and having a molecular mass of 24.0 kDa. ;PDCD6 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

PDCD1Human Programmed Cell Death 1 Human Recombinant Protein

PROTQ15116 Regular: 10ug
EUR 380.4
Description: PDCD1 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 392 amino acids (21-170a.a.) and having a molecular mass of 44.0kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).;PDCD1 is expressed with a 239 amino acids hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.

PDCD4 Programmed Cell Death 4 Human Recombinant Protein

PROTQ53EL6 Regular: 10ug
EUR 380.4
Description: PDCD4 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 469 amino acids and having a molecular mass of 51 kDa.

Programmed Death 1/ Rat Programmed Death 1 ELISA Kit

ELA-E0515r 96 Tests
EUR 1063.2

Recombinant Programmed Cell Death Protein 6 Interacting Protein (PDCD6IP)

4-RPB247Hu01
  • EUR 550.08
  • EUR 271.20
  • EUR 1732.80
  • EUR 657.60
  • EUR 1195.20
  • EUR 444.00
  • EUR 4152.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Programmed Cell Death Protein 6 Interacting Protein expressed in: E.coli