Ago2 Antibody, Brachyury Antibody, Cd45Ro Antibody, Cdk5 Antibody, Erg Antibody, Foxa2 Antibody, Guinea, Hamster, Helicobacter, Horse, Influenza, Insect, Jmjd3 Antibody, Kangaroo, Killifish, Klf2 Antibody, Lkb1 Antibody, Pig, Rabbit, Raccoon, Rat, Reindeer, Reptile, Zeb2 Antibody

Concanavalin A Hepatitis

In addition to, ConA-treated mice contained elevated numbers of activated pure killer (NK) cells, T cells, and NK T cells, which confirmed sturdy cytotoxic train in opposition to murine lymphoma cells in ex vivo assays. That’s moreover translated proper right into a strongly diminished number of liver nodules upon ConA remedy of colon cancer-bearing mice (colon-26), an affect that was abrogated upon NK cell depletion (Fig. 4A). Of observe, NK cells in immunodeficient nude mice (lacking NKT and T cells) weren’t activated upon ConA remedy, suggesting a job of the adaptive immune system in activating NK cells [74].

Concanavalin A (Con A) is a plant lectin that is purified from jack beans. Con A binds to the mannose residues of various glycoproteins and prompts lymphocytes. When Con A is run to mice, liver harm that can rely upon the activation of T lymphocytes by macrophages occurs (Tiegs et al., 1992).

Because of this truth, the model might allow the study of the pathophysiology of immunologically mediated hepatic points, resembling AIH. TNF-α and IFN-γ play important roles in Con A–induced liver harm (Gantner et al., 1995; Kusters et al., 1996) and IL-10 prevents liver harm on this model (Di Marco et al., 1999; Louis et al., 1997). Blood ranges of IL-2, IL-4, and IFN-γ dramatically improve after administration of Con A (Wang et al., 2012). Major drawbacks of this model embrace the dearth of circulating autoantibodies and quick hepatocyte harm following a single-dose Con A injection, which is not a typical attribute of persistent AIH.

 

Lectins as modulators of autophagy in most cancers immunotherapy

Concanavalin A prompts T cells and pure killer cells and triggers anticancer immune responses

Since ConA is a well-known T cell mitogen it’d moreover set off anticancer immune responses by activating tumor explicit CTLs. Actually, remedy of hepatoma-bearing mice (ML-14a cells) with ConA (7.5 mg/kg) strongly diminished liver tumor formation and prolonged survival, whereby 40% of the animals had been tumor free on the end of the experiment [8]. Lymphocytic infiltrates spherical tumor nodules had been observed in ConA-treated animals, suggesting T cell mediated responses. Actually, the depletion of CD8+ T cells totally abrogated the therapeutic outcomes of ConA, whereas the depletion of CD4+ T cells solely partly prevented ConA-mediated inhibition of tumor formation (Fig. 4A). According to this study, ConA triggered CD4+ and CD8+ T cell activation in mice as confirmed by the upregulated expression of CD69 [74].

 

Concavalin A
Concavalin A

Furthermore, all outcomes had been abrogated in IFNγ knock-out mice, displaying the importance of an vigorous immune response. Nonetheless, the remedy with ConA of hepatoma-bearing SCID mice moreover significantly inhibited liver tumor formation, nevertheless solely on the best dose of 20 mg/kg [8]. As SCID mice lack purposeful lymphocytes, these info counsel a direct cytotoxic influence of ConA in direction of the most cancers cells. Actually, ConA induced direct autophagy-dependent cell demise in these mice (see above paragraph about ConA and most cancers cell demise). Thus, ConA prompts CD8+ CTLs and NK cells that in the reduction of in vivo tumor progress and potentiate ex vivo tumor cell lysis (Fig. 4A).

 

Recombinant Programmed Cell Death Protein 1 (PD1)

RPU58652-1mg 1mg
EUR 2808

Recombinant Programmed Cell Death Protein 1 (PD1)

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EUR 470.3

Recombinant Programmed Cell Death Protein 1 (PD1)

RPU53502-100ug 100ug
EUR 554.4

Recombinant Programmed Cell Death Protein 1 (PD1)

RPU53502-1mg 1mg
EUR 2457

Recombinant Programmed Cell Death Protein 1 (PD1)

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EUR 445.5

Recombinant Programmed Cell Death Protein 1 (PD1)

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EUR 564.3

Recombinant Programmed Cell Death Protein 1 (PD1)

RPU53816-1mg 1mg
EUR 2501.2

Recombinant Programmed Cell Death Protein 1 (PD1)

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EUR 453.2

Recombinant Programmed Cell Death Protein 6 (PDCD6)

4-RPL096Hu01
  • EUR 593.09
  • EUR 282.00
  • EUR 1894.08
  • EUR 711.36
  • EUR 1302.72
  • EUR 472.80
  • EUR 4555.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Programmed Cell Death Protein 6 expressed in: E.coli

Recombinant Programmed Cell Death Protein 5 (PDCD5)

4-RPL105Hu01
  • EUR 580.19
  • EUR 278.40
  • EUR 1845.70
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  • EUR 463.20
  • EUR 4434.24
  • 100 ug
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  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Programmed Cell Death Protein 5 expressed in: E.coli

Recombinant Programmed Cell Death Protein 1 (PDCD1)

4-RPA751Hu01
  • EUR 612.44
  • EUR 286.80
  • EUR 1966.66
  • EUR 735.55
  • EUR 1351.10
  • EUR 484.80
  • EUR 4736.64
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Programmed Cell Death Protein 1 expressed in: E.coli

Recombinant Programmed Cell Death Protein 1 (PDCD1)

4-RPA751Ra01
  • EUR 603.84
  • EUR 285.60
  • EUR 1934.40
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  • EUR 480.00
  • EUR 4656.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Programmed Cell Death Protein 1 expressed in: E.coli

Recombinant Programmed Cell Death Protein 6 (PDCD6)

RPU53272-100ug 100ug
EUR 542.3

Recombinant Programmed Cell Death Protein 6 (PDCD6)

RPU53272-1mg 1mg
EUR 2402.4

Recombinant Programmed Cell Death Protein 6 (PDCD6)

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EUR 435.6

Recombinant Programmed Cell Death Protein 5 (PDCD5)

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EUR 528

Recombinant Programmed Cell Death Protein 5 (PDCD5)

RPU52490-1mg 1mg
EUR 2337.4

Recombinant Programmed Cell Death Protein 5 (PDCD5)

RPU52490-50ug 50ug
EUR 423.5

Recombinant Human Programmed cell death protein 5 (PDCD5)

RPC21797-100ug 100ug
EUR 460.9

Recombinant Human Programmed cell death protein 5 (PDCD5)

RPC21797-1mg 1mg
EUR 2237.8

Recombinant Human Programmed cell death protein 5 (PDCD5)

RPC21797-20ug 20ug
EUR 258.7

Recombinant Human Programmed cell death protein 2 (PDCD2)

RPC28416-100ug 100ug
EUR 635.8

Recombinant Human Programmed cell death protein 2 (PDCD2)

RPC28416-1mg 1mg
EUR 2885.2

Recombinant Human Programmed cell death protein 2 (PDCD2)

RPC28416-20ug 20ug
EUR 353.4

PDCD5 Programmed Cell Death-5 Human Recombinant Protein

PROTO14737 Regular: 20ug
EUR 380.4
Description: PDCD5 Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 125 amino acids and having a molecular mass of 14 kDa.

Recombinant Human Programmed cell death protein 10 Protein, His-SUMO, E.coli-1mg

QP8043-ec-1mg 1mg
EUR 1958.4

Recombinant Programmed Cell Death Protein 1 Ligand 1 (PDL1)

RPU43426-100ug 100ug
EUR 554.4

Recombinant Programmed Cell Death Protein 1 Ligand 1 (PDL1)

RPU43426-1mg 1mg
EUR 2457

Recombinant Programmed Cell Death Protein 1 Ligand 1 (PDL1)

RPU43426-50ug 50ug
EUR 445.5

Recombinant Programmed Cell Death Protein 1 Ligand 1 (PDL1)

RPU43427-100ug 100ug
EUR 517

Recombinant Programmed Cell Death Protein 1 Ligand 1 (PDL1)

RPU43427-1mg 1mg
EUR 2293.2

Recombinant Programmed Cell Death Protein 1 Ligand 1 (PDL1)

RPU43427-50ug 50ug
EUR 415.8

Recombinant Programmed Cell Death Protein 1 Ligand 2 (PDL2)

RPU43428-100ug 100ug
EUR 542.3

Recombinant Programmed Cell Death Protein 1 Ligand 2 (PDL2)

RPU43428-1mg 1mg
EUR 2402.4

Recombinant Programmed Cell Death Protein 1 Ligand 2 (PDL2)

RPU43428-50ug 50ug
EUR 435.6

Recombinant Programmed Cell Death Protein 1 Ligand 1 (PDL1)

RPU59529-100ug 100ug
EUR 578

Recombinant Programmed Cell Death Protein 1 Ligand 1 (PDL1)

RPU59529-1mg 1mg
EUR 2515.5