Ago2 Antibody, Brachyury Antibody, Cd45Ro Antibody, Cdk5 Antibody, Erg Antibody, Foxa2 Antibody, Guinea, Hamster, Helicobacter, Horse, Influenza, Insect, Jmjd3 Antibody, Kangaroo, Killifish, Klf2 Antibody, Lkb1 Antibody, Pig, Rabbit, Raccoon, Rat, Reindeer, Reptile, Zeb2 Antibody

Concanavalin A Hepatitis

In addition to, ConA-treated mice contained elevated numbers of activated pure killer (NK) cells, T cells, and NK T cells, which confirmed sturdy cytotoxic train in opposition to murine lymphoma cells in ex vivo assays. That’s moreover translated proper right into a strongly diminished number of liver nodules upon ConA remedy of colon cancer-bearing mice (colon-26), an affect that was abrogated upon NK cell depletion (Fig. 4A). Of observe, NK cells in immunodeficient nude mice (lacking NKT and T cells) weren’t activated upon ConA remedy, suggesting a job of the adaptive immune system in activating NK cells [74].

Concanavalin A (Con A) is a plant lectin that is purified from jack beans. Con A binds to the mannose residues of various glycoproteins and prompts lymphocytes. When Con A is run to mice, liver harm that can rely upon the activation of T lymphocytes by macrophages occurs (Tiegs et al., 1992).

Because of this truth, the model might allow the study of the pathophysiology of immunologically mediated hepatic points, resembling AIH. TNF-α and IFN-γ play important roles in Con A–induced liver harm (Gantner et al., 1995; Kusters et al., 1996) and IL-10 prevents liver harm on this model (Di Marco et al., 1999; Louis et al., 1997). Blood ranges of IL-2, IL-4, and IFN-γ dramatically improve after administration of Con A (Wang et al., 2012). Major drawbacks of this model embrace the dearth of circulating autoantibodies and quick hepatocyte harm following a single-dose Con A injection, which is not a typical attribute of persistent AIH.

 

Lectins as modulators of autophagy in most cancers immunotherapy

Concanavalin A prompts T cells and pure killer cells and triggers anticancer immune responses

Since ConA is a well-known T cell mitogen it’d moreover set off anticancer immune responses by activating tumor explicit CTLs. Actually, remedy of hepatoma-bearing mice (ML-14a cells) with ConA (7.5 mg/kg) strongly diminished liver tumor formation and prolonged survival, whereby 40% of the animals had been tumor free on the end of the experiment [8]. Lymphocytic infiltrates spherical tumor nodules had been observed in ConA-treated animals, suggesting T cell mediated responses. Actually, the depletion of CD8+ T cells totally abrogated the therapeutic outcomes of ConA, whereas the depletion of CD4+ T cells solely partly prevented ConA-mediated inhibition of tumor formation (Fig. 4A). According to this study, ConA triggered CD4+ and CD8+ T cell activation in mice as confirmed by the upregulated expression of CD69 [74].

 

Concavalin A
Concavalin A

Furthermore, all outcomes had been abrogated in IFNγ knock-out mice, displaying the importance of an vigorous immune response. Nonetheless, the remedy with ConA of hepatoma-bearing SCID mice moreover significantly inhibited liver tumor formation, nevertheless solely on the best dose of 20 mg/kg [8]. As SCID mice lack purposeful lymphocytes, these info counsel a direct cytotoxic influence of ConA in direction of the most cancers cells. Actually, ConA induced direct autophagy-dependent cell demise in these mice (see above paragraph about ConA and most cancers cell demise). Thus, ConA prompts CD8+ CTLs and NK cells that in the reduction of in vivo tumor progress and potentiate ex vivo tumor cell lysis (Fig. 4A).

 

Programmed Cell Death Protein 10 (PDCD10) Antibody

20-abx214660
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Programmed Cell Death Protein 10 (PDCD10) Antibody

abx037524-100ug 100 ug
EUR 391
  • Shipped within 5-10 working days.

Programmed Cell Death Protein 10 (PDCD10) Antibody

abx236237-100ug 100 ug
EUR 481
  • Shipped within 5-12 working days.

Programmed Cell Death Protein 10 (PDCD10) Antibody

20-abx310610
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Programmed Cell Death Protein 10 (PDCD10) Antibody

20-abx002091
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
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Programmed Cell Death Protein 10 (PDCD10) Antibody (HRP)

20-abx310611
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Programmed Cell Death Protein 10 (PDCD10) Antibody (FITC)

20-abx310612
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Programmed Cell Death Protein 10 (PDCD10) Antibody (Biotin)

20-abx310613
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
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Mouse Programmed cell death protein 10, Pdcd10 ELISA KIT

ELI-14591m 96 Tests
EUR 865

Human Programmed cell death protein 10, PDCD10 ELISA KIT

ELI-20923h 96 Tests
EUR 824

Human Programmed Cell Death Protein 10 (PDCD10) ELISA Kit

abx382112-96tests 96 tests
EUR 911
  • Shipped within 5-12 working days.

Chicken Programmed cell death protein 10, PDCD10 ELISA KIT

ELI-35614c 96 Tests
EUR 928

Programmed Cell Death 5 Protein

20-abx262104
  • EUR 4490.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug
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Programmed Cell Death 6 Protein

20-abx262735
  • EUR 328.00
  • EUR 6397.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg
  • Shipped within 5-10 working days.

Programmed Cell Death 4 Protein

20-abx262858
  • EUR 328.00
  • EUR 6397.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg
  • Shipped within 5-10 working days.

Recombinant Programmed Cell Death Protein 1 (PDCD1)

4-RPA751Hu01
  • EUR 510.37
  • EUR 239.00
  • EUR 1638.88
  • EUR 612.96
  • EUR 1125.92
  • EUR 404.00
  • EUR 3947.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: Q15116
  • Buffer composition: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 14.0kDa
  • Isoelectric Point: 8.6
Description: Recombinant Human Programmed Cell Death Protein 1 expressed in: E.coli

Recombinant Programmed Cell Death Protein 1 (PDCD1)

4-RPA751Ra01
  • EUR 503.20
  • EUR 238.00
  • EUR 1612.00
  • EUR 604.00
  • EUR 1108.00
  • EUR 400.00
  • EUR 3880.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: D3ZIN8
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 57.4kDa
  • Isoelectric Point: 6
Description: Recombinant Rat Programmed Cell Death Protein 1 expressed in: E.coli

Recombinant Programmed Cell Death Protein 6 (PDCD6)

4-RPL096Hu01
  • EUR 494.24
  • EUR 235.00
  • EUR 1578.40
  • EUR 592.80
  • EUR 1085.60
  • EUR 394.00
  • EUR 3796.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: O75340
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 22.5kDa
  • Isoelectric Point: Inquire
Description: Recombinant Human Programmed Cell Death Protein 6 expressed in: E.coli

Recombinant Programmed Cell Death Protein 5 (PDCD5)

4-RPL105Hu01
  • EUR 483.49
  • EUR 232.00
  • EUR 1538.08
  • EUR 579.36
  • EUR 1058.72
  • EUR 386.00
  • EUR 3695.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: O14737
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 17.9kDa
  • Isoelectric Point: Inquire
Description: Recombinant Human Programmed Cell Death Protein 5 expressed in: E.coli

Recombinant Human Programmed Cell Death 5

7-05830 5µg Ask for price

Recombinant Human Programmed Cell Death 5

7-05831 20µg Ask for price

Recombinant Human Programmed Cell Death 5

7-05832 1mg Ask for price

Recombinant Human Programmed Cell Death 6

7-05833 2µg Ask for price

Recombinant Human Programmed Cell Death 6

7-05834 10µg Ask for price

Recombinant Human Programmed Cell Death 6

7-05835 1mg Ask for price

Recombinant Human Programmed cell death protein 10 Protein, His-SUMO, E.coli-100ug

QP8043-ec-100ug 100ug
EUR 408

Recombinant Human Programmed cell death protein 10 Protein, His-SUMO, E.coli-10ug

QP8043-ec-10ug 10ug
EUR 200

Recombinant Human Programmed cell death protein 10 Protein, His-SUMO, E.coli-1mg

QP8043-ec-1mg 1mg
EUR 1632

Recombinant Human Programmed cell death protein 10 Protein, His-SUMO, E.coli-200ug

QP8043-ec-200ug 200ug
EUR 634

Recombinant Human Programmed cell death protein 10 Protein, His-SUMO, E.coli-500ug

QP8043-ec-500ug 500ug
EUR 1060

Recombinant Human Programmed cell death protein 10 Protein, His-SUMO, E.coli-50ug

QP8043-ec-50ug 50ug
EUR 263

PDCD1Human Programmed Cell Death 1 Human Recombinant Protein

PROTQ15116 Regular: 10ug
EUR 317
Description: PDCD1 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 392 amino acids (21-170a.a.) and having a molecular mass of 44.0kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).;PDCD1 is expressed with a 239 amino acids hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.

PDCD4 Programmed Cell Death 4 Human Recombinant Protein

PROTQ53EL6 Regular: 10ug
EUR 317
Description: PDCD4 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 469 amino acids and having a molecular mass of 51 kDa.

PDCD5 Programmed Cell Death-5 Human Recombinant Protein

PROTO14737 Regular: 20ug
EUR 317
Description: PDCD5 Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 125 amino acids and having a molecular mass of 14 kDa.

PDCD6 Programmed Cell Death 6 Human Recombinant Protein

PROTO75340 Regular: 10ug
EUR 317
Description: PDCD6 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 211 amino acids (1-191a.a.) and having a molecular mass of 24.0 kDa. ;PDCD6 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Programmed Cell Death 6 Interacting Protein

20-abx260576
  • EUR 2861.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 25 ug
  • 5 ug
  • Shipped within 5-10 working days.

PDCD1/Programmed cell death protein 1

E21-D91 10ug
EUR 343